Bladder cancer
INACTIVE --- New hope for patients progressing after first-line treatment for mUCaBartholomeus (75 years old)
Bartholomeus, Bart to his friends, is a 75-year-old amateur rower. Every day he takes his rowing boat to the nearby river and rows for over 2 hours. His arm muscles are gigantic compared to his otherwise skinny body.
He was diagnosed with high-grade urothelial MIBC T2N0M0 and underwent neoadjuvant dd-MVAC followed by a radical cystectomy. 3 months after completing neoadjuvant chemotherapy a CT scan revealed multiple lung and bone metastases. He started pembrolizumab 2 months ago and presents again today.
Assessment summary:
- ECOG PS: 1
- Haemoglobin: 12.5 g/dl
- No peripheral neuropathy
- No hearing impairment
- GFR: 62 ml/min
- CT scan reveals new and enlarging lung lesions
- FGFR2/3 mutation status in diagnostic biopsy specimen: wild type