Bladder cancer
INACTIVE --- It’s getting personalised: first-line therapy of synchronous or metachronous mUCa

Helena (72 years old)

Helena is a 72-year-old woman who loves cooking. On Sundays, she invites the whole family to enjoy a home-cooked, 5-course meal served with appropriate wines.

She was diagnosed with high-grade MIBC T2N0M0 and underwent neoadjuvant dd-MVAC followed by radical cystectomy. First follow-up scans were normal. 15 months after surgery, she presents with lung metastasis.

Assessment summary:

  • ECOG PS: 0
  • Biopsy of lung metastasis compatible with UCa
  • Peripheral neuropathy grade I
  • No hearing impairment
  • GFR: 45 ml/min
  • Tumour sample from cystectomy specimen stains strongly positive for PD-L1

Which treatment option would you choose for this patient?