Bladder cancer
INACTIVE --- New hope for patients progressing after first-line treatment for mUCa

Amelia (66 years old)

Amelia is a 66-year-old retired nurse. Now she is teaching all her grandchildren how to perform CPR. She was diagnosed 8 months ago with UCa of the bladder metastatic to the lungs and was treated with gemcitabine + cisplatin.

The first scan showed a reduced metastatic burden, however, at the end of chemotherapy, the CT scan revealed new and enlarging lung lesions.

The patient started atezolizumab 3 months ago and presents again today.

Assessment summary:

  • ECOG PS: 1; increasing breathlessness and cough
  • CT scan showed further tumour progression
  • FGFR2/3 mutation status in diagnostic biopsy specimen: wild type

Which treatment option would you choose for this patient?