Breast cancer
INACTIVE --- Adjuvant systemic treatment of luminal A/B early breast cancer

Sandra (59 years old)

Sandra, 59 years old, is a veterinarian specialised in farm animals. She has 3 dogs that she often walks with along the sea shore, nearby her home. The results of her screening mammogram were abnormal.

Assessment summary

  • No relevant medical history or family history of cancer
  • Postmenopausal
  • Stage and tumour biology (core biopsy) at diagnosis:
    • cT2N0M0
    • G2, invasive carcinoma of no special type, ER 100%, PgR 90%, HER2 negative (IHC 0), Ki67 30%
  • Breast conserving surgery with oncoplastic techniques + SLNB
  • Pathology report:
    • G2 bifocal invasive carcinoma, 27 mm in largest foci, pT2
    • Intermediate grade DCIS in 15%
    • Lymphovascular invasion present, no perineural invasion
    • R0 resection
    • pN0 (0/4 sn)
  • Multidisciplinary board meeting:
    • Gene expression profiling (21-gene assay): recurrence score result of 21
    • Postoperative RT and systemic therapy

Which systemic treatment option would you choose for this patient?