Breast cancer
UPDATED --- Systemic therapy for HER2-positive early breast cancer

Laura (58 years old)

Laura is a 58-year-old sales agent. After her mother was diagnosed with breast cancer, Laura started self-examining her breast and felt a little lump in her left breast. Mammography and biopsy were performed and unfortunately Laura was diagnosed with breast cancer as well.

Assessment summary

  • Postmenopausal
  • Mother diagnosed with breast cancer at 81 years of age
  • No relevant medical history
  • ECOG PS: 0
  • Tumour size: cT1c (12 mm), LN status: cN0
  • Tumour biology: ER 90%, PgR 30%, HER2 IHC 3+, G3
  • CT scan thorax/abdomen: cM0
  • Surgical and radiation therapy is planned, endocrine therapy is planned after surgery

Which chemotherapy and anti-HER2 treatment option would you choose for this patient (considering SLNB is negative)?