Annie (64 years old)

Annie is a 64-year-old cashier in the local supermarket. In her free time, she is very creative and makes her own greeting cards. She was diagnosed with primary bone metastatic ccRCC on the left side 9 months ago.

Assessment summary:

• Histology confirmed with biopsy
• At least cT3a cN0 cM1 with infiltration of left renal vein
• IMDC: poor risk
• MSKCC: high risk
• Medical history: pulmonary embolism, tricuspid insufficiency grade I, left ventricular load
• First-line therapy with nivolumab + ipilimumab
  • Progressive disease, newly diagnosed pulmonary and bone metastases
  • Progression-free survival: 3 months