Renal Cell Carcinoma
INACTIVE --- Second-line therapy in metastatic ccRCCCharlie (72 years old)
Charlie is a 72-year-old retired army officer. He was diagnosed with metastatic ccRCC 2 years ago with histologically confirmed lung and adrenal gland metastasis.
Assessment summary:
- ECOG PS: 0
- KPS: 100%
- No relevant past medical history
- IMDC: intermediate risk
- 1st-line therapy with pazopanib (800 mg/day) for 4 months, partial remission
- Therapy break for 6 months due to elevated liver enzymes
- Restaging at end of 6 month therapy break showed stable disease
- Liver enzymes declined after 6 month therapy break
- Rechallenge with pazopanib 400 mg/day for 2 months
- Treatment discontinued due to elevated liver enzymes (WHO grade 3)
- Restaging: progression of lung metastasis on CT