Petra (64 years old)

Petra, 64 years old, intended to train for a 10 km walk after her treatment for early stage TNBC. Unfortunately, her physical condition never allowed her to properly start training, and now she is diagnosed with mTNBC.

Assessment summary

• Postmenopausal
• Cancer family history: mother had ovarian cancer at the age of 70 years
  • Genetic panel analysis: no pathogenic variants in BRCA1/2 and PALB2
• Medical history
  • Hashimoto-thyroiditis (well-controlled hypothyroidism, normal thyroid function parameters under l-thyroxin 50 µg/d), mild arterial hypertonia
  • Diagnosis early stage TNBC (cT2N1M0, right side)
    • Neoadjuvant anthracycline-taxane chemotherapy
    • Mastectomy, sentinel lymphadenectomy and targeted axillary dissection (pCR: ypT0 ypN0)
• Today, 16 months later, staging including CT scan of chest/abdomen and bone scan
  • 2 suspicious liver lesions and multiple suspicious pleural lesions
  • Biopsy (liver lesion)
    • Breast cancer, ER 0%, PgR 0%, HER2 IHC 1+, G2
    • PD-L1 status: CPS 6, IC score 5%
• ECOG PS: 0