Wesley (67 years old)

Wesley, 67 years old, was diagnosed with high-volume, high-risk mHSPC 2 years ago (PSA 456 ng/ml, multiple bone metastases) and treatment with ADT + docetaxel was started (within clinical trial). After 6 cycles, his PSA dropped to 5 ng/ml.

Current situation, 1.5 years after stopping docetaxel:

• No comorbidities
• Family history:
  • Father died of PCa at age of 64 years
  • Brother diagnosed with high-risk PCa at age of 61 years
• Germline testing: BRCA2 carrier
• ECOG PS: 0
• Asymptomatic
• Rising PSA: 98 ng/ml
• Testosterone: 17 ng/dl (0.59 nmol/l)
• CT and bone scan: pelvic and retroperitoneal LNs, progression of bone metastases