Case 2: Artur

Artur, 71 years old, has a history of PCa.

Medical history:

• Diagnosed with high-volume mHSPC 4 years ago
  • PSA: 128 ng/ml
  • Bone and CT scan: multiple bone metastases
  • Treatment with ADT + enzalutamide was started
  • PSA nadir was 0.7 ng/ml

Current situation:

• ECOG PS: 0
• Symptoms: mild back pain, under control with NSAIDs
• Bone and CT scan: progression of bone metastases, few positive pelvic and retroperitoneal lymph nodes (all <3 cm), no visceral metastases
• PSMA-PET/CT: concordant with CT and bone scan, all lesions PSMA positive and higher PSMA expression than liver
• Testosterone: 19 ng/dl (0.7 nmol/L)
• Somatic tumour testing: ATM mutation