Maria (45 years old)

Maria, a 45-year-old woman, enjoys working in her own little vineyard. Unfortunately, she fell on her back during work. An X-ray showed a suspicious lesion in the spine. A further diagnostic workup was performed which showed metastatic breast cancer.

Assessment summary:

• Premenopausal
• No relevant medical history, ECOG PS: 0
• No family history of breast cancer
• Imaging:
  • 4 cm tumour in the left breast, 3 suspicious axillary lymph nodes
  • Multiple suspicious lesions in the spine
  • 2 lesions suspicious for metastases in the liver
• Biopsy of bone metastasis: breast cancer, NST, ER 90%, PgR 60%, HER2 IHC 1+, G2
• Haematology and biochemistry: all values normal
• Germline BRCA-status: wild type
• PIK3CA-status in the tumour: wild type