Prostate cancer
INACTIVE --- mCRPC: novel and emerging agentsWilfred (69 years old)
Wilfred, 69 years old, regularly attends board game nights with his son. He was diagnosed with PCa 4 years ago.
- Family history:
- Father died of PCa at age of 90 years
- Mother died of breast cancer at age of 67 years
- Medical history:
- 4 years ago: RT + 6 months of ADT for cT3 ISUP grade 3 (GS 4+3) PCa, PSA 21 ng/ml
- 6 months after RT: PSA nadir 0.7 ng/ml
- 2 years after RT: PSA 29 ng/ml, bone and CT scan: multiple bone lesions and retroperitoneal LNs. Treatment with ADT + enzalutamide started (PSA decreased to 0.3 ng/ml)
- 3.5 years after RT: disease progression in pelvic/retroperitoneal LNs, PSA 102 ng/ml, testosterone 17 ng/dl. Treatment with docetaxel started
- Current situation (4 years after RT)
- ECOG PS: 1
- Mild pelvic pain
- CT and bone scan: progression in bone, pelvic and retroperitoneal LNs
- Rising PSA: 110 ng/ml
- Somatic BRCA2 mutation found in biopsy of primary tumour