Nadia (56 years old)

Nadia, a 56-year-old woman, was diagnosed with metastatic ccRCC 5 years ago and has been treated with sunitinib ever since. Although several pulmonary metastases are seen still seen on the CT scan, she still has a partial response. The primary tumour appears to be largely necrotic on imaging.

Assessment summary:

• ECOG PS: 0
• KPS: 90%
• Suffers from severe toxicity related to sunitinib (uncontrolled hypertension, hyperthyroidism)
• Blood work:
  • Decreased TSH
  • Elevated T3 and T4
  • Otherwise normal