Bladder cancer
Molecular diagnostics in the era of targeted therapies for mUCa

Saad (72 years old)

Saad, 72 years old, manages a charming coffee shop, where he serves delicious brews and warm hospitality to regulars who have become like family over the years. Unfortunately, 2 years ago he was diagnosed with primary mUCa with retroperitoneal lymph node and lung metastasis.

  • Partial response after 6 cycles of gemcitabine + cisplatin
  • Ongoing maintenance avelumab without side effects
  • Last CT scan: new mediastinal lymphadenopathy
  • Lymph node biopsy confirmed a metastasis of UCa

Assessment summary:

  • Medical history: mild hypertension, hyperthyroidism
  • ECOG PS: 1
  • Peripheral neuropathy: grade 1 due to prior cisplatin
  • No hearing impairment
  • GFR: 70 ml/min

Which of the following actions would you choose for this patient?