Johanna (72 years old)

Johanna, 72 years old, was diagnosed with metastatic breast cancer 1 year ago, after she had been treated for early HR+ HER2- breast cancer 8 years ago.

Assessment summary:

• Postmenopausal
• Medical history:
  • HR+ HER2- breast cancer T2N0M0 8 years ago. Treated with breast conserving surgery, radiation therapy and letrozole for 5 years
  •  
  • Diagnosis metastatic disease 1 year ago (bones, liver). Biopsy of liver metastasis: breast cancer, NST, ER 90%, PgR 60%, HER2 IHC 1+, G2. Endocrine monotherapy with anastrozole was started
  • Tumour regression in control imaging
  • ECOG PS: 0
• No family history of breast cancer
• Most recent CT scan of chest and abdomen and bone scan:
  • Stable multiple bone metastases
  • Progression of 2 liver metastases
• Haematology and biochemistry: all values normal
• Germline BRCA-status: wild type
• PIK3CA-status in the tumour: wild type