Tanja (45 years old)

Tanja, 45 years old, has been complaining for the last 4-5 weeks of a severe lumbar back pain. Due to the persistence of the pain after some days of rest, she has decided to go to her doctor who prescribed her an X-ray. The X-ray showed a suspicious lesion in the spine. A further diagnostic workup was performed which showed metastatic breast cancer.

Assessment summary:

• Premenopausal
• ECOG PS: 0
• Congenital long QT syndrome; no other significant medical history
• No family history of breast cancer
• Imaging:
  • 2 cm tumour in the left breast, 1 suspicious axillary lymph node
  • Multiple suspicious lesions in the spine compatible with breast cancer metastasis
• Biopsy of the breast lesion: breast cancer, NST, ER 90%, PgR 60%, HER2 IHC 0, G2
• Haematology and biochemistry: all values normal
• Germline BRCA-status: wild type