Brenda (44 years old)

Brenda is 44 years old and has a history of early stage TNBC. During treatment, she received a lot of support from her sister, with whom she created small traditions like going to the cinema before each dose of chemotherapy. Unfortunately, Brenda is now diagnosed with mTNBC.

Assessment summary

• Premenopausal
• Family history
  • Aunt died of breast cancer at age 56 years
• Genetic testing: BRCA1 mutation
• No comorbidities
• ECOG PS: 1
• Medical history
  • 14 months ago: diagnosis early stage TNBC (cT1N1M0)
    • Neoadjuvant chemotherapy with anthracycline-taxane + carboplatin
    • Bilateral mastectomy + ALND (pCR: ypT0 ypN0)
• Today, CT scan of the chest and abdomen revealed 3 lung lesions
  • Biopsy (lung lesion)
    • Breast cancer, ER 0%, PgR 0%, HER2 IHC 0, Ki67 40%, G2
    • PD-L1 status: CPS 15, IC score 0%