Prostate cancer
High-risk non-metastatic prostate cancer

Claude (62 years old)

Claude, 62 years old, dominates the bridge table, reading opponents like a book. Yet, behind his competitive façade, he guards a secret passion for cheesy romance novels, a world he escapes to with a mischievous grin. He was recently diagnosed with PCa during a check-up.

Assessment summary:

  • Medical history: no relevant comorbidities or medication
  • ECOG PS: 0
  • PSA: 19 ng/ml
  • Clinical stage (DRE): cT3a
  • mpMRI: PI-RADS 5 lesion left apical-mid peripheral zone, extracapsular extension, prostate volume 44 ml, no bulky median lobe
  • Prostate biopsy: ISUP grade group 3 (Gleason score 4+3)
  • CT (abdomen/pelvis) + bone scan, or PSMA-PET/CT: no signs of positive LNs or distant metastasis

Which of the following treatment options would you choose as a next step for this patient?