Breast cancer
Systemic therapy for HER2-positive early breast cancer

Anita (68 years old)

At 68 years old, Anita is a very popular elderly social media influencer. She loves receiving free clothes and accessories, but ends up donating most of the goodies to charity since her closet is overflowing.
Unfortunately, she got diagnosed with HER2-positive breast cancer.
 

Assessment summary

  • Postmenopausal
  • Medical history: surgical repair torn cruciate ligament
  • ECOG PS: 0
  • Initial tumour size: cT2 (38 mm), initial LN status: cN0
  • Tumour biology: ER 40%, PgR 30%, HER2 IHC 3+, G3
  • CT scan chest/abdomen and bone scan: no metastases
  • Neoadjuvant therapy: anthracycline/taxane + trastuzumab
  • Surgical therapy: breast conserving surgery and SLNB
    • Pathology report: no residual invasive disease: ypT0, ypN0 (0/3 sn)
  • Adjuvant therapy: regimen consisting of anti-HER2 therapy with an aromatase inhibitor + radiation therapy

Which option would you choose for this patient?