Bladder cancer
Adjuvant treatment approaches for MIBC

Celia (72 years old)

Celia is a 72-year-old retired chemical engineer, who now enjoys brewing beer at home with her grandson.

She was recently diagnosed with MIBC (cT3bN0M0) and received 3 cycles of neoadjuvant gemcitabine + cisplatin (GC) followed by RC + PLND.

Postoperative assessment summary:

  • eGFR: 65 ml/min
  • ECOG PS: 1
  • CT imaging: cM0
  • Cardiac ejection fraction: 70%
  • Pathological review RC specimen:
    • ypT3N0 (0/10)
    • Negative surgical margins (R0)
    • PD-L1 negative

Which of the following treatment options would you choose for this patient?