Christian (76 years old)

Christian, 76 years old with a history of chronic kidney disease associated with hypertension, has turned his passion for chess into a weekly event, hosting friendly tournaments in his living room where neighbours gather for a quiet afternoon of strategy and storytelling.

He initially presented with UCa of the bladder with lung metastases and was treated with gemcitabine + carboplatin. After 6 cycles of chemotherapy, he has now progressive disease.

Assessment summary:

• ECOG PS: 2
• No peripheral neuropathy
• No hearing impairment
• GFR: 35 ml/min
• Haemoglobin: 9.8 g/dl (anaemia grade 2)
• CT scan reveals worsening of lung and new liver metastases
• FGFR2/3 alteration status in metastatic biopsy specimen: activating FGFR3 mutation