Prostate cancer
High-risk non-metastatic prostate cancer

Bradley (59 years old)

Bradley, 59 years old, has been a fortune biscuit writer for the past 20 years. Now he thinks he has run out of luck as he was recently diagnosed with PCa.

Assessment summary:

  • Medical history & comorbidities:
    • Minimal LUTS (IPSS: 7), on tamsulosin
    • Type 2 diabetes mellitus, on metformin
  • ECOG PS: 0
  • PSA: 9 ng/ml
  • Clinical stage (DRE): cT2b
  • mpMRI: PI-RADS 3 lesion lateral left, no extracapsular extension, prostate volume 44 ml, no bulky median lobe
  • Prostate biopsy: ISUP grade group 4 (Gleason score 3+5)
  • CT (abdomen/pelvis) + bone scan, or PSMA-PET/CT: no signs of positive LNs or distant metastasis

Which of the following treatment options would you choose as a next step for this patient?