Wilson (72 years old)

Wilson, 72 years old, helps out at an amateur radio station and is a member of the local church choir. He was diagnosed with high-risk PCa 9 years ago (pT3aN0, ISUP grade 4, postoperative PSA <0.1 ng/ml). The disease progressed to mCRPC 5 years ago (bone). He received enzalutamide as first-line and 6 cycles docetaxel as second-line therapy.

Follow-up today (1 year after completion of docetaxel treatment):

• No comorbidities
• No relevant family history
• ECOG PS: 1
• Fairly well controlled pain (VAS score 3)
• Rising PSA: 110 ng/ml
• PSMA-PET/CT: progression in bone only (all lesions with PSMA expression)
• Somatic (tumour) testing: no mutation identified