Caroline (36 years old)

Caroline, 36 years old, works as a pilates instructor in her free time. After giving classes, she usually takes a bath to relax her muscles. While taking a bath, she recently felt a lump in the left breast.

Assessment summary

• Premenopausal
• No family history of breast and ovarian cancer
• No relevant medical history, ECOG PS: 0
• Tumour size: cT2 (33 mm), LN status: cN1
• Tumour biology:
  • Ductal invasive carcinoma of NST
  • ER 0%, PgR 0%, HER2 IHC 0
  • Ki67 70%
  • G3
• CT scan chest/abdomen and bone scan: no metastases
• Genetic testing: no BRCA1/2 mutation
• Primary systemic therapy (including LHRH analogue): 4 cycles of pembrolizumab + paclitaxel + carboplatin, followed by 4 cycles of pembrolizumab + doxorubicin + cyclophosphamide
• BCS + SLNB
• Pathology report: no residual tumour (stage ypT0N0)