Douglas (72 years old)

Douglas is a 72-year-old best-selling fiction author. He was diagnosed with metastatic ccRCC 2 years ago with histologically confirmed lung and adrenal gland metastasis.

Assessment summary:

• ECOG PS: 0
• KPS: 100%
• Severe Crohn’s disease
• IMDC: intermediate risk
• First-line therapy with pazopanib (800 mg/day) for 4 months, partial remission
• Therapy break for 6 months due to elevated liver enzymes
  • Restaging at end of 6 month therapy break showed stable disease
  • Liver enzymes declined after 6 month therapy break
• Rechallenge with pazopanib 400 mg/day for 2 months
  • Treatment discontinued due to elevated liver enzymes (WHO grade 3)
  • Restaging: progression of lung metastasis on CT