Martina (54 years old)

Martina is 54 years old and used to work as a consultant. She was diagnosed with early stage TNBC at the age of 51. Unfortunately, tumour progression was detected a week ago.

Assessment summary

• Postmenopausal
• No relevant family history
• Genetic testing: no gBRCA1/2 pathogenic variants
• No relevant comorbidities
• ECOG PS: 0
• Medical history
  • 3 years ago, diagnosed with early stage TNBC (cT3N2M0, right side)
    • Neoadjuvant chemotherapy: anthracycline-taxane + carboplatin
    • Mastectomy (right side) and ALND (no pCR: ypT1 ypN1)
    • Post-mastectomy radiation therapy
    • Post-neoadjuvant capecitabine (6 cycles)
  • 1 year ago, staging including CT scan of chest/abdomen and bone scan: 2 liver lesions
    • Biopsy (liver lesion)
      • Breast cancer, ER 0%, PgR 0%, HER2 IHC 0, G3
      • PD-L1 status: CPS 3, IC score 4%
    • Therapy with atezolizumab + nab-paclitaxel for 6 months
• Today, CT scan shows progression of the liver lesions and 2 new lung lesions