Farid (65 years old)

Farid, 65 years old, devotes his time to mentoring young entrepreneurs at a startup incubator, sharing his wisdom and experience to help them succeed. He initially presented with UCa of the bladder with bone and lymph node metastases and was treated with 6 cycles of gemcitabine + cisplatin. After progression with new bone metastases, he received pembrolizumab, but the treatment was stopped after 10 cycles due to grade 4 immune-related colitis.

Assessment summary:

• ECOG PS: 1
• Peripheral neuropathy: grade 1 due to prior cisplatin
• No hearing impairment
• GFR: 70 ml/min
• Medical history: mild hypertension, hyperthyroidism
• Lymph node biopsy testing results: FGFR3 wild type

After complete recovery from the immune-related colitis, the patient shows disease progression.