Bladder cancer
Management of BCG-pretreated (very) high-risk NMIBC

Mireille (77 years old)

Mireille, a 77-year-old former librarian who enjoys bookbinding, is suspected of having bladder cancer.

Assessment summary:

  • No relevant medical history
  • ECOG PS: 0
  • Cystoscopy: papillary tumour of 4.5 cm at the right bladder wall
  • Urine cytology: negative for HG UCa (according to the Paris system)
  • Conventional TURBT: resection visually complete, pathological review:
    • pT1 HG
    • Pure UCa
    • No LVI
    • Muscle in specimen
  • Second TURBT: no residual disease
  • CT urography: cN0, no concomitant upper tract tumour

BCG induction was started and followed by maintenance BCG. 9 months after start of BCG therapy (i.e. BCG induction and 2 courses of BCG maintenance completed), the patient presents with a papillary tumour of 1 cm near the previous resection side. Conventional TURBT confirms pTa HG (muscle in specimen, no LVI).

Which of the following treatment options would you choose for this patient?