Marc (73 years old)

Marc is a 73-year-old business analyst. He is diagnosed with metastatic bladder cancer during a workup for dysuria.

Assessment summary:

• Former smoker (30 pack years)
• Medical history: hypertension
• CT scan of chest, abdomen and pelvis: bone and lung metastases, biopsy compatible with UCa
• ECOG PS: 1
• No peripheral neuropathy, diabetes mellitus or autoimmune condition
• Audiometric hearing loss: grade 1
• GFR: 90 ml/min
• Cardiac ejection fraction: 60%
• PD-L1 expression: positive
• FGFR2/3 alteration status in metastatic biopsy specimen: wild type