Prostate cancer
mCRPC: novel and emerging agents

Wayde (66 years old)

Wayde, 66 years old, is an active member of the local book club. Every month, he meets with a group of 10 people to discuss the books they have read. He was diagnosed with mCRPC for which he already received 3 lines of therapy (docetaxel, enzalutamide, cabazitaxel).

Current situation:

  • ECOG PS: 1
  • Mild bone pain
  • CT and bone scan: progressive bone metastases, no visceral metastases
  • Rising PSA: 78 ng/ml
  • PD-L1 positive
  • Molecular testing: MMR-deficient

Which of the following treatment options would you choose for this patient?