Lucius (75 years old)

Lucius, a 75-year-old retired diplomat, hosts lively geopolitical debates with his friends. His passion for global affairs keeps his minds sharp and engaged.

He was diagnosed with urothelial muscle-invasive bladder cancer (MIBC) cT2N0M0. He underwent immediate radical cystectomy (RC) without receiving neoadjuvant chemotherapy. The pathological review of the RC specimen indicated pT3 pN0 (0/10) R0, PD-L1 negative. Following RC, the patient received 4 cycles of adjuvant gemcitabine + cisplatin, which was well tolerated.

He presents with liver metastases 5 months after completing adjuvant chemotherapy.

Assessment summary:

• Former smoker (20 pack years)
• No relevant medical history
• ECOG PS: 1
• Haemoglobin: 12.5 g/dl
• Peripheral neuropathy: grade 1
• No hearing impairment
• GFR: 70 ml/min
• CT scan reveals diffuse liver metastases, biopsy compatible with UCa
• FGFR2/3 alteration status in metastatic biopsy specimen: activating FGFR3 mutation