Prostate cancer
mCRPC: novel and emerging agentsWilly (73 years old)
Willy, 73 years old, loves bird watching. He put several seed and nut feeders in his garden to attract birds. He spends hours a day to identify the different species and to study their behaviour. He was diagnosed with PCa 7 years ago.
Medical history:
- 7 years ago: RP for PCa (pT3bN0, ISUP grade 5, postoperative PSA <0.1 ng/ml)
- 6 years ago: salvage RT for rising PSA (0.53 ng/ml)
- 5 years ago: ADT started because of rising PSA (7 ng/ml), no metastases on conventional imaging
- 2 years ago: progression to mCRPC (bone), 1st-line treatment with abiraterone, 2nd-line treatment with 6 cycles docetaxel
Current situation:
- Rising PSA: from 0.9 ng/ml to 3.9 ng/ml
- ECOG PS: 1
- Back pain
- MRI spine:
- Progression of existing bone lesions and new bone lesions in multiple vertebrae
- Enlarging soft tissue component at Th9 causing spinal cord compression
- Neurosurgical decompression was performed
- Histology from neurosurgical decompression: metastatic poorly-differentiated PCa
- Somatic ATM mutation