Melissa (46 years old)

Melissa, 46 years old, fell off the ladder during window cleaning. Although it was a mild trauma, she broke her thigh bone. An X-ray showed a fracture due to suspected bone metastases. Further diagnostic work-up revealed mTNBC with bone metastases.

Assessment summary

• Premenopausal
• Cancer family history
  • Aunt (father’s sister): unilateral breast cancer at the age of 45 years
• Medical history
  • 3 years ago: diagnosis early stage TNBC (cT2N0M0, left side)
  • Neoadjuvant anthracycline-taxane chemotherapy
  • BCS + SLNB (pCR: ypT0 ypN0)
  • Radiation therapy
• Present diagnostic work-up including CT scan chest/abdomen and bone scan
  • Multiple bone lesions. Biopsy (bone lesion left femur): breast cancer, ER 0%, PgR 0%, HER2 IHC 0, Ki67 40%, G3
  • 2 suspicious lesions in left lung
• No relevant comorbidities
• ECOG PS: 0