Jasmine (70 years old)

Jasmine, 70 years old, spends her days volunteering at the local food bank, distributing meals to those in need. Unfortunately, she was diagnosed with muscle-invasive bladder cancer (MIBC), for which she received 4 cycles of neoadjuvant gemcitabine + cisplatin before radical cystectomy (RC) 6 months ago.

Assessment summary:

• ECOG PS: 1
• Medical history: Hashimoto’s thyroiditis, rheumatoid arthritis
• TURBT at initial diagnosis: minimal pT2 UCa cN0M0
• Pathological review RC specimen: ypT2 ypN+ (3/18), lymphatic and vascular invasion, negative surgical margins

A recent CT scan showed new bilateral pulmonary nodes.

• Pathological review of pulmonary node biopsy: confirmed a UCa metastasis

Her oncologist suggests testing FGFR3 alterations for further treatment decisions.