Jean-Luc (78 years old)

Jean-Luc, 78 years old and a retired microbiologist, regularly invites his granddaughters to inspect tap water under the microscope, sharing his passion for the unseen world and sparking their curiosity about science.

He is diagnosed with metastatic UCa of bladder.

Assessment summary:

• Medical history: obesity
• CT scan of chest, abdomen and pelvis: diffuse liver and bone metastases, biopsy compatible with UCa
• ECOG PS: 1
• No peripheral neuropathy
• No hearing impairment
• GFR: 40 ml/min
• PD-L1 expression: low

The patient completed 4 cycles of gemcitabine + carboplatin with stable disease and maintenance with avelumab was started. After 5 cycles, the patient had partial response (complete remission of the diffuse liver metastases, but 4 bone metastases remaining). At this time, he experienced watery diarrhoea, cramping, urgency, and abdominal pain. Stool evaluation ruled out an infection. A diagnosis of grade 3 colitis was made and the patient was hospitalised for in-patient care.