Bladder cancer
Immunotherapy and antibody-drug conjugates: handling AEs and special populationsAlessandro (74 years old)
Alessandro, 74 years old, loves pizza, even the ones topped with pineapple. He doesn’t dare to tell his Italian family and friends …
He was diagnosed 10 months ago with UCa of the bladder metastatic to the pelvic lymph nodes and lungs and was treated with gemcitabine + cisplatin. The first scan showed a reduced metastatic burden; however, at the end of chemotherapy, the CT scan revealed new and enlarging lung lesions.
The patient started pembrolizumab, but 6 months later he shows again progressive disease.
Assessment summary:
- No relevant medical history
- ECOG PS: 1; increasing breathlessness and cough
- CT scan of chest, abdomen and pelvis: new and enlarged lesions in the lungs
- FGFR2/3 mutation status in diagnostic biopsy specimen: wild type