Eric (58 years old)

Eric, 58 years old, was diagnosed with locally advanced bladder cancer with lung and liver metastases. He is on first-line treatment with cisplatin plus gemcitabine.

First follow-up scan after the 4^th cycle showed progressive disease with a brain metastasis that was treated with stereotactic radiosurgery. He requires a daily dose of prednisone 50 mg.

• Medical history: hypertension
• CT scan of chest, abdomen and pelvis: diffuse liver and lung metastases
• ECOG PS: 0
• GFR: 75 ml/min
• PD-L1: low
• FGFR2/3 mutation status in diagnostic biopsy specimen: wild type