Prostate cancer
mCRPC: novel and emerging agents

Winston (56 years old)

Winston is a 56-year-old taxi driver in London and has a superb driving record. He never got a penalty for speeding. In addition, he has a thorough knowledge of the streets and knows the quickest routes through the complicated road network. He was diagnosed with mHSPC 3 years ago (PSA 456 ng/ml, multiple bone metastases) and treatment with ADT + abiraterone was started. His PSA dropped to 5 ng/ml.

Current situation:

  • No comorbidities
  • Family history:
    • Father died of PCa at age of 62 years
    • Brother diagnosed with high-risk PCa at age of 59 years
  • ECOG PS: 0
  • Asymptomatic
  • Rising PSA: 98 ng/ml
  • Testosterone: 17 ng/dl
  • CT and bone scan: pelvic and retroperitoneal LNs, progression of bone metastases

Which of the following options would you choose for this patient, if you have access to molecular testing and targeted therapies?