Renal Cell Carcinoma
First-line systemic therapy in metastatic renal cell carcinomaHarry (44 years old)
Harry, aged 44, started working in a logistical centre of food supplements a few months ago, but is struggling to carry out his work activities. He recently presented with haematuria and asthenia.
Assessment summary:
- CT scan: revealed a large right renal mass and diffuse liver lesions
- cT2bN0M1
- Kidney mass biopsy: WHO/ISUP grade 3 ccRCC
- ECOG PS: 2 (due to haematuria and asthenia)
- KPS: 70%
- Medical history: active but controlled uncomplicated ulcerative colitis, treated with mesalazine
- No family history of cancer
- Blood work:
- Haemoglobin: 11.2 g/dl (12-13 g/dl)
- Neutrophils: 8.2x109/l (2.0-7.0x109/l)
- Platelets: 680x109/l (150-400x109/l)
- Calcium: 9.0 mg/dl (8.5-10.2 mg/dl)
- LDH: 420 U/l (135-225 U/l)