Renal Cell Carcinoma
First-line systemic therapy in metastatic renal cell carcinoma

Harry (44 years old)

Harry, aged 44, started working in a logistical centre of food supplements a few months ago, but is struggling to carry out his work activities. He recently presented with haematuria and asthenia.

Assessment summary:

  • CT scan: revealed a large right renal mass and diffuse liver lesions
  • cT2bN0M1
  • Kidney mass biopsy: WHO/ISUP grade 3 ccRCC
  • ECOG PS: 2 (due to haematuria and asthenia)
  • KPS: 70%
  • Medical history: active but controlled uncomplicated ulcerative colitis, treated with mesalazine
  • No family history of cancer
  • Blood work:
    • Haemoglobin: 11.2 g/dl (12-13 g/dl)
    • Neutrophils: 8.2x109/l (2.0-7.0x109/l)
    • Platelets: 680x109/l (150-400x109/l)
    • Calcium: 9.0 mg/dl (8.5-10.2 mg/dl)
    • LDH: 420 U/l (135-225 U/l)

Which of the following treatment options would you choose for this patient?