Abby (59 years old)

Abby, 59 years old, works as a teacher in the primary school of her town. She was diagnosed with de novo metastatic breast cancer.

Assessment summary:

• Postmenopausal
• No relevant comorbidities or family history
• Diagnosis de novo HR+ HER2- metastatic breast cancer with multiple bone and lymph node metastases (axillary, cervical, mediastinal)
  • Tumour biology (lymph node lesion): invasive carcinoma of NST, ER 30%, PgR 10%, HER2 IHC 1+, Ki67 40%
• First-line treatment: CDK4/6i + letrozole
  • CT scan after 3 months: disease progression, with increase of all existing lesions; 2 new bone lesions