Joanna (58 years old)

Joanna, 58 years old, was diagnosed with primary metastatic breast cancer.

Assessment summary:

• Postmenopausal
• No relevant comorbidities or family history
• Diagnosis de novo HR+ HER2- metastatic breast cancer with multiple spine and liver metastases
  • Tumour biology (liver lesion): invasive carcinoma of NST, ER 90%, PgR 40%, HER2 IHC 1+, Ki67 30%
• First-line treatment: CDK4/6i + letrozole
  • CT scan after 3 months: partial response
  • CT scan after 6 months (3 additional months): stable disease
  • CT scan after 12 months (6 additional months): stable disease in spine, new multiple lesions in liver (accompanied with severe organ dysfunction: GOT 10x ULN, GPT 9x ULN, bilirubin 2x ULN), absence of biliary tract obstruction. She presents with loss of appetite, weight loss, and increased fatigue.