Tracy (72 years old)

Tracy, 72 years old former actress, enjoys sitting by the fire in her cosy living room, tracing old script notes with a wistful smile.

She was diagnosed with metastatic breast cancer 3 years ago, after she had been treated for early HR+ HER2- breast cancer 12 years ago.

Assessment summary:

• Postmenopausal
• No family history of breast cancer
• ECOG PS: 0
• Medical history:
  • HR+ HER2- breast cancer T2N0M0 12 years ago. Treated with breast conserving surgery, radiation therapy and letrozole for 5 years
  • Diagnosis metastatic disease 3 years ago (bones, liver). Biopsy of liver metastasis: breast cancer, NST, ER 90%, PgR 60%, HER2 IHC 1+, G2. Treatment with abemaciclib + anastrozole was started
• Tumour regression in control imaging
• Most recent CT scan of chest and abdomen and bone scan:
  • Stable multiple bone metastases
  • Progression of 2 liver metastases
• Haematology and biochemistry: all values normal
• Somatic PIK3CA mutation status: wild type
• Somatic ESR1 mutation status (on liquid biopsy): wild type
• Germline BRCA mutation status: BRCA1 mutation