Luis (69 years old)

Luis is 69 years old, and still happily runs a local jazz bar. He was diagnosed with high-grade non-muscle-invasive bladder cancer (NMIBC) without CIS and underwent induction with Bacillus Calmette-Guérin (BCG) (6/6 instillations). At follow-up cystoscopy 6 weeks after the last BCG cycle (e.g. 3 months after the start of BCG), a tumour was found at the bladder neck.

Assessment summary:

• No relevant medical history
• Maximal TURBT, visually complete
• Pathological review:
  • pT2 UCa
  • Unifocal, no concomitant CIS
• Transurethral biopsy of the prostatic urethra, pathological review:
  • No prostatic urethral involvement
• Imaging: suggestive for cT2 cN0 cM0
• Ultrasound: no hydronephrosis
• eGFR: 66 ml/min
• No peripheral neuropathy
• No hearing impairment
• ECOG PS: 1
• Cardiac ejection fraction: 70%

Concurrent RT + cisplatin is planned.