Bladder cancer
Management of BCG-pretreated (very) high-risk NMIBC

Cornelia (72 years old)

Cornelia, a 72-year-old retired naval officer, presented with episodes of macroscopic haematuria.

Assessment summary:

  • Medical history:
    • Hypertension
    • Moderate chronic obstructive pulmonary disease
  • ECOG PS: 1
  • Cystoscopy:
    • 2 papillary tumours: 1 in the trigone, 1 in the right bladder wall
    • Largest tumour diameter: 3.5 cm
  • Urine cytology: HG UCa (according to the Paris system)
  • Conventional TURBT: resection visually complete, pathological review:
    • pTa HG
    • Pure UCa
    • No LVI
    • Muscle in specimen
  • CT urography: cN0, no concomitant upper tract tumour

BCG induction was started. After the third dose of BCG induction, the patient presents with a strong, persistent urge to urinate, a burning feeling when urinating and microscopic haematuria without fever or other systemic symptoms. The patient was put on non-steroidal anti-inflammatory drugs (NSAIDs), but symptoms did not improve after 1 week.

A urine sample is collected and sent to the lab to be cultured.

Which of the following options would you choose for this patient?