Bladder cancer
UPDATED --- Targeted therapies for metastatic UCa in special populations

Heather (70 years old)

Heather, 70 years old, spends her days listening to audiobooks that make her dream about fantastic adventures.

She is diagnosed with metastatic UCa of the bladder.

Assessment summary:

  • Medical history: diabetes
  • CT scan of chest, abdomen and pelvis: lung metastases
  • ECOG PS: 1
  • No peripheral neuropathy
  • No hearing impairment
  • GFR: 60 ml/min
  • PD-L1 expression: low

The patient completed 6 cycles of gemcitabine + cisplatin with complete response but has developed grade 2 peripheral neuropathy (PNP) and grade 1 fatigue. The patient receives duloxetine for her neuropathic pain.

Which of the following options would you choose for this patient?