Bladder cancer
INACTIVE --- New hope for patients progressing after first-line treatment for mUCaDavid (81 years old)
David is an 81-year-old retired firefighter. Every month he meets up with his ex-colleagues for a game of cards and a walk down memory lane.
He was diagnosed with UCa of the bladder with metastases to the liver. He was cisplatin-ineligible due to an impaired GFR. His tumour was strongly positive for PD-L1. He started pembrolizumab. Now, 18 months after initiation of pembrolizumab, he has a follow-up visit.
Assessment summary:
- ECOG PS: 1
- Peripheral neuropathy grade I
- GFR: 45 ml/min
- CT scan: new liver lesions
- FGFR2/3 mutation status in diagnostic biopsy specimen: activating FGFR3 gene fusion