Bladder cancer
UPDATED --- First-line therapy of synchronous and metachronous metastatic UCaElio (74 years old)
Elio is a 74-year-old former accountant who now enjoys solving complex crossword puzzles.
He completed 4 cycles of neoadjuvant gemcitabine + cisplatin before undergoing RC and pelvic lymph node dissection for MIBC.
Post-operative outcomes:
- Pathological review: ypT2bN2 (3/10)
- Imaging: suggestive for cM0
He started adjuvant nivolumab therapy 5 months ago.
Assessment summary today (9 months after last dose of neoadjuvant chemotherapy):
- No relevant medical history, except for elevated creatinine after chemotherapy
- ECOG PS: 1
- CT scan of chest, abdomen and pelvis: intrathoracic lymph node metastases, biopsy compatible with UCa
- No peripheral neuropathy
- No audiometric hearing loss
- GFR: 48 ml/min
- FGFR2/3 alteration status in metastatic biopsy specimen: wild type