Breast cancer
CDK4/6 inhibitors for everyone? First-line treatment strategies in HR+ HER2- MBCConny (54 years old)
Conny is a 54-year-old hair stylist who had been feeling bad for weeks. She had a resistant cough, felt tired and suffered from back pain and nausea. As she was too busy with her own hair salon, she did not see a doctor until she felt so sick that she was unable to eat and could hardly breathe. A diagnostic work-up showed advanced breast cancer.
Assessment summary:
- Postmenopausal
- Medical history: smoking (40 pack years), chronic obstructive pulmonary disease
- Imaging:
- 7 cm tumour in the left breast, multiple suspicious axillary lymph nodes
- Multiple suspicious lesions in bones, lung, pleura, huge pleural effusion, 4 liver lesions suspicious for metastases
- A drainage of the pleural effusion was performed but did not alleviate the dyspnoea, that now persists at rest
- Biopsy of liver lesion: breast cancer, NST, ER 30%, PgR 10%, HER2 IHC 1+, G2
- Haematology: all values normal; biochemistry: GOT 10x ULN, GPT 9x ULN, bilirubin 2x ULN, other values normal