Bladder cancer
First-line therapy of synchronous and metachronous metastatic UCaJacob (73 years old)
Jacob, 73 years old, is the former owner of a popular bar at the seaside. He now enjoys a quiet life with his wife in their beach house.
He is diagnosed with metastatic bladder cancer during a workup for dysuria.
Assessment summary:
- Former smoker (30 pack years)
- Medical history: hypertension
- CT scan of chest, abdomen and pelvis: bone and lung metastases
- Biopsy compatible with UCa
- ECOG PS: 1
- No peripheral neuropathy
- Audiometric hearing loss grade 1
- Glomerular filtration rate (GFR): 90 ml/min
- Cardiac ejection fraction: 70%
- PD-L1 expression: strongly positive