Breast cancer
UPDATED --- Adjuvant systemic treatment of luminal A/B early breast cancer in postmenopausal women

Cora (59 years old)

Cora, 59 years old, is a veterinarian specialised in farm animals. She has 3 dogs that she often walks with along the seashore, nearby her home. The results of her screening mammogram were abnormal.

Assessment summary

  • No relevant medical history
  • No family history of cancer
  • Postmenopausal
  • Stage and tumour biology (core biopsy) at diagnosis:
    • cT2N0M0
    • G2, invasive carcinoma of NST, ER 100%, PgR 90%, HER2 IHC 0, Ki67 30%
  • BCS with oncoplastic techniques + SLNB
  • Pathology report:
    • G2 bifocal invasive carcinoma, 27 mm in largest foci, pT2
    • Intermediate grade DCIS in 15%
    • LVI present, no perineural invasion
    • R0 resection (free margins)
    • pN0 (0/4 sn)
  • Multidisciplinary board meeting:
    • Gene expression profiling: low risk
    • Postoperative RT and systemic therapy + bisphosphonates

Which of the following systemic treatment options would you choose for this patient?